Consequently, filter technique has employed to many approaches, for instance, SLP methods [4], SQP methods [5, 6], interior point approaches [7] and derivative-free optimization [8, 9].
It uses the Successive Quadratic Programming (SQP) [40] on the optimization framework of gPROMS software [41] and it is proved to be very capable [39].
The paired comparisons were designated Cell Line Pair A (clones 3B12 (SQp) versus 5B5 (NSQp)) and Cell Line Pair B (clones 2.8 (SQp) versus 1.14 (NSQp)).
SQP-1 were obtained from Guangdong YiHeTang Pharmaceutical Co., Ltd.
Twenty pills weigh 1 g for both SQP-1 and SQP-2.
The diarylheptanoids' content levels in SQP-2 were 3 5 times higher than SQP-1.
In the bottom panel, the content level variation was normalized based on the contents in SQP-1 sample.
However, for the most of the other constituents, the content levels in SQP-2 sample were larger than SQP-1 sample.
As shown in Figure 3, it was worth noting that the significant content variation between the SQP-1 sample and SQP-2 sample was observed.
As for linderane, a marker compound for quality control in current Chinese Pharmacopeia [6], the mean content levels (132 μg/g for SQP-1 and 266 μg/g for SQP-2) were superior to the mandatory criteria (i.e., no less than 90 μg/g) albeit the 2-fold difference between the two products.
(lot no.20111210, expiration: 2013/11; Chinese SFDA ratification no.Z44023146; Zhongshan, Guangdong Province, China) and SQP-2 were purchased from Guangdong HuaTianBao Pharmaceutical Group (lot no.1110103, expiration: 2014/09; Chinese SFDA ratification no. Z44023538; Foshan, Guangdong Province, China).
