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Mean decline in peak flow during sputum induction was 13.2±2.1%.
Sputum induction provides an opportunity to directly sample secretions from the lower respiratory tract.
Sputum induction is increasingly used as a research technique and as a clinical tool.
Healthy subjects (n = 60) underwent metabolic, blood counts, urinalysis, sputum induction, and chest and abdomen magnetic resonance imaging.
This study provides useful information for investigators designing trials of anti-inflammatory therapies in CF involving sputum induction.
A protocol for sputum induction which restricts the use of hypertonic saline based on lung function is both safe and effective in subjects with moderate to severe COPD.
This retrospective study was designed to evaluate the safety and efficacy of a bronchoprotective sputum induction protocol in moderate to severe chronic obstructive pulmonary disease (COPD).
Forty-two adults with COPD (FEV1 = 51.7±3.2% predicted (mean±SEM)) underwent sputum induction using a protocol designed to minimize hypertonic saline-induced bronchoconstriction.
The value of sputum induction in pediatric asthma lies in its potential to directly and noninvasively assess airway inflammation in children, because bronchoscopy and biopsy carry some risk.
Sputum induction is a tool to monitor airway inflammation, yet it may induce by itself a neutrophilic response when repeated within 24 to 48 h.
Alternately, sputum induction with inhalation of hypertonic saline mist has been used to obtain adequate sputum samples [17, 18].
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