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It is, however, clear that robust validation of novel CRC predisposition loci is required to avoid spurious testing.
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This automated method consists in identifying spurious tests and withdraw them from the final statistical analysis.
"It is significant that influential figures on the right have made clear their view that dividing children up according to a spurious academic test pre-puberty is a surefire way to depress educational opportunity for working-class children," she says.
Lastly, with no control for false discovery rates and multiple testing, spurious results are possible and, as such, the results should be interpreted with caution.
They reasoned that refusing the tests would mean there would be no spurious data for test-based teacher evaluations.
When performing many simultaneous tests spurious significant results can be expected both in proof of difference and proof of equivalence.
46 Patients who thus meet the criteria for a second operation must necessarily live longer making the argument circular and the statistical test spurious.
For example, when we investigated the results more carefully, we discovered SNPs in which the minor allele was present in few individuals, and such individuals could be almost perfectly identified by a seemingly random combination of phenotypes, leading to a large spurious canonical correlation test score (or, equivalently, a highly significant P-value).
After the interaction number M i ′ was determined using the AIC order detection and Student's t-test, spurious false-positive PPIs, α ^ i j, in (2) were pruned away, and only significant PPIs that remained were refined as follows: (3) x i n = ∑ j = 1 M i ′ α ^ i j x j n + w i ′ n, i = 1,2, …, M where M i ′ ≤ M i denotes the number of significant PPIs of the PPIN, with the target protein i.
After P values were determined using the AIC order detection and Student's t-test, spurious false positive PPIs α ^ i j in (2) were pruned away and only the significant PPIs that remained were refined as follows: (3) x i (n ) = ∑ j = 1 M i ′ α ^ i j x j (n ) + w i ′ (n ), i = 1,2 … M, where M i ′ ≤ M i denotes the number of significant PPIs of PPIN, with the target protein i.
The study examined association with many risk factors, and some of the reported findings may therefore be spurious due to multiple testing.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com