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A notorious refinement of this was to be found in the 2005 sci-fi movie The Island, directed by Michael Bay, which contained a spurious sequence showing a fluttering butterfly -- spurious, that is, until you realised that it was a subliminal logo placement for MSN, the software company.
The recognition of regions of disorder is thus crucial to avoid spurious sequence alignments with sequences of unrelated, structured proteins.
Collectively, the above findings strongly suggest that certain domains have the propensity to attract spurious sequence similarity during homology search.
Sequencing errors or spurious sequence alignments can both lead to SVs calls by the split-read analysis.
Disordered regions often have a biased amino acid composition that can lead to spurious sequence similarity with unrelated proteins.
The new method is based on a guide tree; to detect possible spurious sequence similarities, it employs a vertex-cover approximation on a conflict graph.
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Following random re-sampling, to equalize sample size to that of the smallest sample (4070 sequences) and enable comparison based on equal sequencing effort [10], and de-noising (i.e. the removal of spurious sequences based on the SLP technique), the bacterial community contained 999 distinct OTUs (please refer to methods for the level of demarcation for the OTUs).
Firstly, the extended search requires a much larger database of putative sequences, with a corresponding rise in the amount of time and space required to analyse the data, and secondly, the extended database will also contain a large number of spurious sequences, some of which may match the experimental data by chance [22], [31], [32], [35].
The latter is largely responsible for the spurious sequence-to-domain hits and the situation is made worse when used with the local-mode only HMMER3.
The combination of draft genome with automated gene finding software can result in spurious sequences.
All spurious sequences or poorly aligned regions were discarded with trimAL (with –gt 0.5).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com