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Additional spurious linkage was obtained with regions on chromosomes 2, 6, 11, 12, and 15 (0.05>p>0.01) (Table 2; Fig. 4A, B).
This spurious linkage disequilibrium should quickly dissipate with periodic recombination and population growth [32], provided the introduced population has not lost sexual competence.
A LOD score of 5.0 with a maximum recombination of 45% was used to assign markers to linkage groups with the exception for LG6 and LG11, where a LOD score of 8.0 and 9.0, respectively, was applied to break spurious linkage according to Muchero et al. (2009).
Hence, whenever a trait shows a spurious linkage, many correlated traits will likely map to the same locus, creating a spurious expression (e QTL hotspot.
This is relevant since allele frequencies may vary according to race, and mis-specification of allele frequencies may lead to spurious linkage results.
Only LG1b contained any significant markers that had homology to other chromosomes and as they were at the end of the LG could be due to spurious linkage.
Similar(47)
Empirical results show that eNFE improves BB identification by eliminating spurious linkages which occur often in most existing EDAs.
Moreover, segregation distortion can affect marker order, as it creates spurious linkages.
However the complex population history of inbred lines can lead to spurious linkages (Payseur and Place 2007).
Only marker loci that did not show segregation distortion (P < 0.05) were used for the initial map construction to eliminate spurious linkages.
We demonstrate that in expression quantitative trait locus (eQTL) mapping, read alignment to individualized transcriptomes reduces the number of spurious linkages and unmasks extensive local genetic variation affecting gene expression.
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