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Using registry data alone would generally not provide sufficient information to be able to control for these effects and so the analyses may result in a potentially spurious finding.
"It is always possible that this was a spurious finding," acknowledged the authors, from Johns Hopkins University in Maryland.
"When you're doing multiple analyses and splitting this way, that way and the other, the likelihood this is just a spurious finding is greater than the likelihood it's real".
The word "probably" is the one that matters: Goldacre is big on probability, and a relentless scourge of "science" journalism: the kind of lazy hackwork that picks up a spurious finding or a dodgy argument and presents it as evidence of cause and effect.
It is also possible that the significant anticipation of the hit is a spurious finding.
These experiments also confirm that it was PCR error, rather than pyrosequencing that accounts for the spurious finding of K65R.
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But he worries that the possibly "spurious" findings of this study will lead to hasty changes in suture material without fully understanding the risks involved.
If this assumption is violated, the estimates of the standard errors will be too small, a situation that can result in many spurious findings (Hox, 2002).
To avoid spurious findings, sample size and characteristics of the study populations as well as replication studies in an independent study population should be an essential part of a study design.
To minimize the possibility of spurious findings due to population admixture, we used a family-based design applying the sibship disequilibrium test (SDT) as well as two-point parametric linkage analyses on families from the National Institute of Mental Health NIMH Genetics Initiativeve.
When analysing smaller subgroups subsequent to the principal analysis the chance of spurious findings may increase.
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