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Epiboly represents the spreading of embryonic cells over a vegetal yolk mass, resulting in ectoderm to cover the embryo.
The differential cell adhesion hypothesis was originally formulated to explain the sorting out and spreading of embryonic tissues based on adhesion energies between cells (Steinberg, 1975).
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The specific aim of this study was to reveal the effect of the interface of plasma-treated and gold-coated PEEK matrices on adhesion and spreading of mouse embryonic fibroblasts.
Similar adhesion dynamics have also been observed in the spreading of mouse embryonic fibroblasts on fibronectin-coated substrates, and reveal phase transitions during cell spreading.
Similarly, knock-down of PAR-1 in the early embryo leads to abnormal spreading of AJs in the apicolateral region, but in embryonic epithelia PAR-1 is enriched in the apicolateral region versus the basolateral domain [59].
Activation of an epigenetic process called epithelial mesenchymal transition (EMT) is indeed characteristic of embryonic development, of fibrotic or regeneration processes, and of the spreading of cancer cells from their primitive origin [ 1, 2].
In early differentiating female mouse embryonic stem cells (XX ESCs) we observed initial spreading of Xist RNA as distinct foci before chromatin compaction.
Recently Kalluri and Weinberg proposed a classification of EMT: type 1 EMT serves for embryonic development, type 2 for tissue repair and type 3 for metastatic spreading of cancer [ 71].
Stop the spreading of pathogens.
Fears spread of wider unrest.
After further enhancements using the RGDC peptide, the PTMAc-F127-PTMAc hydrogel got significantly improved the adhesion and spread of mouse embryonic fibroblasts cells (NIH/3T3), which indicated the potential of this injectable hydrogel for applications in biomedical engineering.
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