They are an integral part of other molecular interactions in the ECM and inside the cell that govern the properties and behavior of the cell in a wide range of processes such as migration, spreading, differentiation, growth, and healing.
Focal adhesion kinase plays a central role in cell spreading, differentiation, migration, cell death, and acceleration of the G1 to S phase transition of the cell cycle.
The absence of stiffness dependent spreading and differentiation on PDMS, apparently contradictory to previous findings of cell differentiation dependence on substrate stiffness, can be explained by the ability of seeded cells to remodel the collagen layer present on viscoelastic PDMS, diminishing their sensitivity to substrate stiffness.
MC3T3 cell adhesion, spreading, proliferation, differentiation, and gene expression were examined on crosslinked PPF/mPOSS disks.
Crypt-like topography affected Caco-2 spreading and differentiation during early culture, however the effect diminished as culture progressed.
Using this technique, we identified several neotissue microenvironments supporting MSC adhesion, spreading and differentiation toward early vascular lineages.
The quality of the initial cell attachment to a biomaterial will influence any further cell function, including spreading, proliferation, differentiation and viability.
Engineering of the cellular microenvironment has become a valuable means to guide cellular activities such as spreading, motility, differentiation, proliferation, or apoptosis.
Calpains are involved in regulatory cleavage of a number of substrates during cell adhesion, spreading, migration, differentiation, apoptosis and autophagy [19] [21].
In the third step, a combination of BMP4 (10 ng/ml), FGF2 (20 ng/ml) and Activin (30 or 100 ng/ml) was added, leading to spreading and differentiation of the colonies (Figure 3A).
The SUEL lectin in the sea urchin egg has specificity for galactose [ 34]. hPKD1 is involved in mechanotransduction, regulation of cell growth, cell spreading and differentiation [ 12, 13].
