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The cell reactions were investigated concerning adhesion kinetics, migration, spreading, cell adhesion, and collagen I synthesis.
Attenuation of these functions was associated with reduced cell spreading, cell membrane disruptions and loss of cell shape.
They noticed an intriguing pattern: the enzyme was missing in aggressive, rapidly spreading cell lines, and present in the tamer ones.
Although a few focal contacts connected to central filaments are present in the center of the spreading cell, but the spreading margins show no focal contacts.
This suggests that myosin IIB is involved in the regulation of focal contacts formation in the central part of spreading cell.
Myosin IIA and IIB increase cell adhesion by regulating focal contacts formation in the spreading margins and central part of the spreading cell, respectively.
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This program involves cell spreading, cell-cell dissociation, migration, invasion, proliferation and differentiation.
First, after depolymerization of microtubules, spreading cells exhibited morphological oscillations.
No such organized actin network is observed in the spreading cells depleted of myosin IIA.
Scapinin was colocalized with actin at the edge of spreading cells.
Then we apply hypotheses generation to the problem of cortical oscillations of spreading cells [15], [24].
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