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Typical sites for metastasic spread (stage IV disease) are the liver, peritoneal cavity and lungs, all of which occur in 50% or more of fully advanced cases.
Prognostic factors in NSCLC include presence or absence of pulmonary symptoms, tumor size, cell type (histology), degree of spread (stage) and metastases to multiple lymph nodes, and vascular invasion.
To investigate the value of neoadjuvant chemotherapy (NACT), followed by interval debulking surgery (IDS), in endometrial cancer with transperitoneal spread (stage IV).
Given these similarities and given our current findings, we believe that the data obtained in stage IIIc ovarian cancer might be extrapolated to endometrial cancer with transperitoneal spread (stage IV).
In 2001 2002, radiotherapy or chemoradiotherapy would have been the preferred treatment for most women, except those eligible for radical surgery, with extrapelvic spread (stage IVB), the very frail or elderly.
Other independent factors associated with poorer DSS included age (HR: 1.07 95% CI 1.06 1.08); regional spread stage at presentation (HR: 2.36 95% CI 2.04 2.74) and distant spread (HR: 7.65, 95% CI 6.48 9.04) compared to the localized spread.
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Due to the nature of the metastatic spread, staging includes bone scintigraphy, MRI brain and CT chest.
The patients were classified at the discovery of disease, both according to spread (stages I-IV according to the Ann Arbor classification) and to tumour histology (the Kiel classification).
Eligibility criteria were age ⩾18, confirmed pure or mixed histology TCC, and muscle invasive disease and/or nodal or metastatic spread (staged T2 4 and/or N1 3 and/or M1) at first use of chemotherapy.
Smoke detector, device used to warn occupants of a building of the presence of a fire before it reaches a rapidly spreading stage and inhibits escape or attempts to extinguish it.
Real time impedance monitoring data reveals spreading stage completes within 5 h.
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