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"What we've got to avoid at all costs is a geographically spread replication of the system people criticised in the first place".
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However T/A 4 exhibited both enhanced HPIV3 spread and replication compared to controls, in which we had previously observed enhanced IAV replication, suggesting that this cell line may have other properties unrelated to SERPINE1 that promote virus replication and spread.
Infection in neurons or other CNS cell types leads to rapid local production of type I Interferons (IFN) in a bid to curtail virus spread and replication.
Multiple HDIs were tested and Trichostatin A (TSA) was found to potently enhance the spread and replication of a tumour selective vaccinia virus in several infection-resistant cancer cell lines.
The distinct differences in host strain-dependent spread and replication of HSV-1 in the perineurial cell layer might support the hypothesis that the genetic properties of the perineurial cells could possibly have a key role in viral entry to the CNS and progression to HSE.
In our model we saw intense HSV-1 spread and replication in the perineurium of susceptible DA rats, while in the resistant PVG rats the viral levels in the whiskers area decreased over time and remained in the outer part of the epineurium.
Collectively, we conclude that GEM negatively affects the spread and replication of reovirus.
In the absence of effective antibiotic therapy, this may lead to enhanced bacterial spread and replication leading to more severe tissue destruction and lung and systemic organ injury.
Should this be the case, the pathogens could utilize the host-cell machinery to their advantage in facilitating their survival, spread and replication in the fly.
This results in a transient viremia leading to viral spread and replication in target organs followed by a secondary viremia leading to characteristic disseminated cutaneous lesions.
In order to follow the sequential spread and replication of tumor cells, a sensitive method to determine the presence of clonogenic tumor cells in host tissue is required.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com