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Because small businesses must spread regulatory costs over smaller facilities, smaller numbers of employees and smaller annual sales, those costs have a much bigger impact than they do on big businesses.
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This topology included a possible 'higher-order originating regulator hub' that potentially spreads regulatory effects through DAR-FFC-mediated transmissions.
These findings suggest the possibility that KLF12 has the distinctive function of being a 'higher-order originating regulator hub' that potentially spreads regulatory effects through DAR-FFC-mediated transmissions.
Post-transcriptional regulation by small RNAs (sRNAs) in bacteria is now recognized as a wide-spread regulatory mechanism modulating a variety of physiological responses including virulence.
T cells are ranged into three classes: precursor (Tp, i.e. mature but not yet activated by the APC), effector (Te, i.e. cells that will control the pathogen spread) and regulatory T cells (Tr).
If a subsequent mutation in the parental copy causes a slightly impaired function, it is possible that selection could favour the spread of regulatory mutations that restore gradually the function of the parental copy.
But many dotcom business models had been predicated on the wide availability of broadband internet connections, which for regulatory reasons spread more slowly than expected.
Similarly, the gene regulatory elements spread across long regions impose critical constraint on genomic architecture and are known to have maintained exceptionally long syntenic blocks both within and across species [ 46- 48].
string transcription is highly dynamic, dictates the pattern of cell divisions during embryogenesis and is controlled by the activity of developmentally regulated transcription factors binding to cis-regulatory sequences spread over >30 kb of the string locus (Edgar et al., 1994).
Shared polymorphism of the TT haplotype among ISX insertions suggests a model where a mutation that refines regulatory activity arose once at a single TE-derived regulatory element, and spread across elements via non-allelic gene conversion.
Consistent with this are reports of reduced promoter evolutionary constraint between human and chimpanzee [ 23], wide spread cis-regulatory element shuffling [ 24] and mammalian putative regulatory regions that do not align to other mammalian genomes [ 25- 28].
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