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The optic tract and radiation may spread pathology from the optic chiasm to both temporal lobes.
Spinal cord injury (SCI) is a widely spread pathology with currently no effective treatment for any symptom.
Amyloid fibrils are self-propagating entities that spread pathology in several devastating disorders including Alzheimer's disease (AD).
Moreover, γ-syn can be transmitted between cells [ 15] and presumably to spread pathology as was shown for α-syn [ 16– 16].
The claim that α-syn can be transported along long autonomic nervous system structures supports the notion that α-syn is a long distance runner with the ability to spread pathology from one structure to another.
Similar(55)
The first key development is that our data potentially model the "spreading pathology" model of PD championed by Braak.
α-Synucleinopathies are progressive diseases and in recent years there have been increasing efforts to identify the mechanisms involved in intracerebral spread of pathology, as it is reasoned that therapies that could slow or halt pathology spread would likely be disease modifying.
Our case shows that involvement of a particular structure in the eye can sometimes involve an adjacent structure due to contiguous spread of pathology.
Several regulatory genes are critical for virus replication, spread, and pathology, especially tax which is capable of immortalizing lymphoid cells in culture and in mouse model systems.
Since the photoreceptors that degenerate are not dopaminergic, this demonstrates nonautonomous degeneration, and a spread of pathology.
It can then lead to seeding of monomeric tau and further tau aggregation and spread of pathology.
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