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This implies that the treatments are very critical in controlling the spread of malignant cancer.
Since the metastatic spread of malignant tumors accounts for the majority of cancer-specific deaths [116 118], possible correlations between EMT markers and patient prognosis have been intensely studied in multiple tumor entities.
Furthermore, we evaluate a possible correlation between EMT marker expression and patient prognosis as well as current therapeutic concepts targeting the EMT process to slow down or prevent metastatic spread of malignant tumors.
In two previous studies on peritoneal washings before and after manipulation with an intra-uterine device, spread of malignant cells could be demonstrated in 2 out of 82 women with negative peritoneal washings prior to manipulation [22, 23].
Studying the details of tumor host interactions at each of the steps leading up to successful metastatic colonization may therefore pave the way for designing therapeutic strategies to counteract the metastatic spread of malignant tumors.
Computed Tomography (CT) of the abdomen and pelvis after contrast administration is important both in evaluation of spread of malignant lesions and in detection of recurrence after therapy, whereas it has a limited value in primary detection and characterization of an ovarian mass.
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We modelled the spreading of malignant cells in the body via kinetic Monte Carlo simulations to address the dynamical evolution of the metastatic process and to predict the spatial distribution of malignant lesions.
However, mutant p53 proteins gain oncogenic properties favoring the insurgence, the maintenance, and the spreading of malignant tumors [ 22].
Downregulation of CD56 and a higher expression of CD44 have been associated with extramedullary spreading of malignant plasma cells [ 4, 5] and expression of CD28 has been related to disease activity [ 6, 7].
The stroma surrounding the malignant cells is important for the growth and spread of the malignant tumour.
If not, c-Src antagonists may simply reduce the spread of highly malignant ILC cells.
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