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Hence, greater initial activation will result in a greater spread of activation from that initially activated node to other nodes, including those with weaker direct or indirect connections to the initially activated node.
Given the high concentrations of CaMKII in synapses and the fact that calmodulin is limiting (Liu and Storm, 1990; MacNicol and Schulman, 1992; Persechini and Stemmer, 2002), subunit exchange provides a potential mechanism for increasing the spread of activation caused by an initial activating pulse.
When the first and final presentations of the same story were directly compared, significant increments in activation were found in the middle frontal gyrus bilaterally, and the right inferior parietal lobule, suggesting that the spread of activation with re-listening reflected an active neural process over and above that required for comprehension of the text.
More generally, this will lead to an uncontrolled spread of activation and an increase of spontaneous neuronal activity, hence, to a decreased signal-to-noise ratio [34].
The spread of activation could indeed be mediated by the insertion of an active subunit into an inactive one.
They may have nothing to do with whether an adjacent domain is active or repressed; they may only prevent the spread of activation or repression.
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Myogenic hypermethylation might also affect the relative abundance of different RNA isoforms, facilitate transcription termination, help stop the spread of activation-associated chromatin domains and stabilize repressive chromatin structures.
The spreading of activation then decreases over time and/or some intervening activity.
We discuss these findings considering the modulatory top down effects of tDCS on subcortical structures via prefrontal activation, and how spreading of activation might be different for healthy volunteers versus depressed patients.
Priming as classically defined involves the spreading of activation among semantic and conceptual representations and does not necessarily entail an account in which a linguistically-primed object representation influences the operation of putatively lower-level processes involved in the visual detection of that same object.
They found that related probes elicited longer reaction times than neutral probes as a function of automatic spreading of activation in the arithmetic facts lexicon.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com