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During the 2003 SARS epidemic, a total of 132 confirmed SARS patients were reported from these two hospitals, which derived from two completely unrelated super spread events (SSE).
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Also, privileging a spread event, by using sports clusters that include already existing venues, is a successful strategy.
"We will have a spread event today.
In the context of spreading processes this would imply that various ranges of possible contamination would correspond to different distributions of times between successive spreading events.
The time course of the early spreading events in representative cells (bone-specific SCP2, lung-specific SCP3, non-metastatic SCP21, and control MCF10A cells) was quantified (Figure 6).
Rather, the phosphorylation state of Y1065 is the main contributing factor that affects cell spreading events which is likely attributed to interactions with an unidentified binding partner.
To further probe the differences between the Y1065 variants and better understand the impact of Y1065 phosphorylation, we explored the impact of these mutants in cells, particularly during cell spreading events.
The emergence of individual-based modelling allows for more realistic modelling of healthcare worker-patient contact (e.g. super spreading events) or incorporation of heterogeneity in transmission risk profiles of patients.
As a conclusion, the TPE associated with SAg silencing and activation cannot be explained by a simple spreading of telomeric heterochromatin into subtelomeric regions, rather it seems more likely that the TPE influences SAg regulation in combination with a gene specific factor to specifically regulate one individual locus, thus avoiding global spreading events.
Taken together with previous studies that examined actin binding and bundling on cell spreading, it is likely that vinculin-driven F-actin bundling does not play a direct role in dictating cell area during spreading events since the actin bundling-deficient variant, Y1065E vinculin, exhibits a significant increase in the cell area.
After activation and subsequent binding to their ligands, these integrins are capable of transmitting signals into cells (termed outside-in signalling) that induce actin cytoskeleton reorganization and cell spreading events, which increase the overall avidity of cell cell or cell extracellular matrix adhesion.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com