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Spatial patterns of risk, disease clusters and cold and hot spots were generated using a spatial scan statistic and a Getis-Ord Gi* statistic.
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Both data sets were generated using Agilent spotted oligonucleotide microarrays.
For microarray data processing and normalization, microarray chips were scanned using a GenePix 4000B scanner (Axon Instruments, Union City, CA) and median spot intensities were generated using GenePix 5.0 (Axon Instruments, Union City, CA).
A GenePix 4000B scanner (Axon Instruments, Union City, CA, USA) was used to scan individual chips and median spot intensities were generated using GenePix 4.0 (Axon Instruments).
Data were generated using Rosetta NKI-spotted oligonucleotide arrays and were downloaded from http://microarray-pubs.stanford.edu/wound_NKI/explore.html as log 2-transformed values in a text table format.
Images were generated using a Leica spinning-disc confocal microscope and Spot-image analysis software.
Graphics were generated using R36.
Molecular images were generated using UCSF Chimera57.
Sashimi plots were generated using MISO (v.0.5.4).
All figures were generated using Pymol [31].
Graphs were generated using WinMDI (Scripps).
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