Sentence examples for spot sign from inspiring English sources
The CT angiography (CTA) spot sign is a strong predictor of hematoma expansion in intracerebral hemorrhage (ICH).
However, CTA parameters vary widely across centers and may negatively impact spot sign accuracy in predicting ICH expansion.
The number of spot sign positive scans was higher in the calibrated analysis (67.8 vs 38.9% p < 0.001).
CTA images obtained within 8 h from symptom onset were analyzed by two trained readers comparing the calibrated vs. uncalibrated density cutoffs for spot sign identification.
The CT angiography (CTA) spot sign has been proven to be a promising factor predicting haematoma expansion and is recommended as an entry criterion for haemostatic therapy in patients with ICH.
We developed a CT iodine calibration phantom that was scanned at different institutions in a large multicenter ICH clinical trial to determine the effect of image standardization on spot sign detection and performance.A custom phantom containing known concentrations of iodine was designed and scanned using the stroke CT protocol at each institution.
Calibrated CTA images had higher sensitivity for ICH expansion (76 vs 52%) but inferior specificity (35 vs 63%) compared with uncalibrated images.Normalization of CTA images using phantom data is a feasible strategy to obtain consistent image quantification for spot sign analysis across different sites and may improve sensitivity for identification of ICH expansion.
Addition of CT angiography spot sign (odds ratio 4·46, 95% CI 2·95-6·75; p<0·0001) thethe model increased the C-index by 0·05 (95% CI 0·03-0·07).In this large patient-level meta-analysis, models using four or five predictors had acceptable to good discrimination.
We then evaluated relationships between the spot sign and outcomes.
Large hematoma volume, another predictor of spot sign, might be the result of ongoing bleeding expressed as the spot sign.
Death occurred in 17 of 80 patients (21.3 %) with spot sign and 28 of 243 patients (11.5 %) without spot sign, and was thus significantly more frequent with the spot sign (p = 0.0327).
