Therefore, we conclude that cdc6-mn cells undergo sporadic chromosomal replication initiation, although clearly the levels of replication are too low to promote a checkpoint response in the critical period, during which DSBs must be prevented.
However, murine cytomegalovirus (MCMV) infection leads to life-long latency, with sporadic low-level replication [ 1].
When introduced together in the absence of the other mutations, the 3'NTR mutations were not fully compensatory, but they did confer a low level of replication, with sporadic detection of viremia (≤2.5×104 ge/mL) at multiple time points, (T16457 and T16463, Fig. 4E).
The sporadic affected expression of "DNA replication, recombination, and repair" indicated that TTP could also cause DNA damage.
The sporadic affected expression of "DNA replication, recombination, and repair" could be one indication for DNA damage caused by TTP treatment.
A replication sample with 2,200 sporadic AD patients and 2,301 controls was genotyped to confirm our GWAS findings.
As a consequence of their defective MMR, HNPCC/LS tumors and sporadic CRCs display increased rates of replication errors at short repeat sequences, termed microsatellite instability (MSI).
The final sample size for replication was 2235 cases (1528 Sporadic, 707 Familial) and 796 controls, all from the NINDS Repository.
Description of studies included: (S1a) Sixteen Breast Cancer Association Consortium (BCAC) European studies in the discovery analysis; (S1b) Four BCAC Asian studies and Prospective Study of Outcomes in Sporadic versus Hereditary Breast Cancer (POSH) study in the replication analysis.
We cannot also exclude sporadic collapse of a higher number of replication forks in Tipin-depleted extract, consistent with the role of Tipin in maintaining fork stability (Chou and Elledge, 2006; Errico et al, 2007).
In accordance with the observations by Richardson et al. (2006), who reported a higher frequency of Xi loss and Xa replication in BLC respect to non-BLCs, sporadic BLC exhibited a significant lower XIST expression than sporadic non-BLC (p = 0.0002).
