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These simulations also suggest that the timing of disturbances is an important predictor of sporadic accumulation of cancerous cells.
With this platform we now turn to consider the process of on-going clone induction following the sporadic accumulation of somatic mutations.
Alternatively, such a distribution could result from the sporadic accumulation of large insertions in IGRs that are gradually eroded by more frequent deletions.
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For sporadic CRC, the accumulation of genetic and epigenetic alterations is increasingly recognized as a crucial process that induce colonic epithelial cells into colon adenocarcinoma cells [ 17– 17].
Flooding can exert strong influence on the distribution and abundance of soil invertebrates, particularly in arid regions where flooding events are sporadic and water accumulation and drainage variable (Hunter et al., 2001; Adis & Junk, 2002; Plum, 2005).
Thus our results confirm the relationship between mtDNA sequence variation and AD and suggest that both ancient polymorphisms defining sub-haplogroups and the accumulation of sporadic mutations are most likely involved.
Our results indicate that high resolution analysis of inherited mtDNA sequence variation can help in identifying both ancient polymorphisms defining sub-haplogroups and the accumulation of sporadic mutations associated with complex traits such as AD.
However, the mechanisms causing α-synuclein accumulation in sporadic PD are unclear.
Recently, an accumulation of sporadic cases of cutaneous leishmaniasis has been documented in horses originating from Germany and Switzerland [ 36].
In the following section, we discuss how these results must be revised to accommodate on-going induction due to the continuous accumulation of sporadic mtDNA mutations.
There is substantial controversy regarding the causative role of amyloid deposition in AD. 1 In the majority of sporadic AD cases, Aβ accumulation is thought to result from the failure of Aβ clearance from the brain.
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