While previous observations in Corriedale ewes [ 27] were made at the onset of the breeding season, the present experiment was performed in the mid-breeding season, when ewes spontaneously display their maximum reproductive activity.
Transgenic rats over-expressing the HLA-B27 and human β2-microglobulin have been shown to spontaneously display gut disease and peripheral and axial inflammatory arthritis [ 6], but ankylosis was only seen in rats with increased expression of β2-microglobulin, which coincided with reduced gut disease and unfolded protein response [ 7].
Shannon Matthews' neighbourhood, community and family are poor, lacking in resources, and yet they have spontaneously displayed remarkable resourcefulness - children organised a vigil, adults went out searching for the missing child, community intelligence led the police to her.
We previously reported that its young founder Andrey Ternovskiy has enlisted Napster founder Shawn Fanning as an advisor, and the site may start using filters and reputation systems to help weed out users who have a habit of spontaneously displaying their genitals.
We recorded three chromatic patterns – mottled dorsal mantle (MDM), fin edge spots (FES), and all dark (AD) (Fig. 1A) – spontaneously displayed by three un-anesthetized squid loosely fixed in a container.
The Smyth line (SL) chicken is the only animal model for autoimmune vitiligo that spontaneously displays all clinical and biological manifestations of the human disorder.
The Smyth line (SL) chicken is the only animal model for autoimmune vitiligo that spontaneously displays all clinical and biological manifestations of the human disorder [ 2, 3].
Hence, the present study was designed to evaluate the effects of TRC150094 in an animal model that spontaneously displays a phenotype akin to patients with the aforementioned cluster of nontraditional CV risk factors.
Whereas the expression of wild-type human frataxin led to fully functional cells in the absence of endogenous frataxin, cells expressing mutant forms of human frataxin spontaneously displayed characteristics of FRDA, including Fe-S cluster deficit, mitochondrial iron accumulation and deposits, and sensitivity to oxidative stress (Calmels et al., 2009; Schmucker et al., 2011).
Finally, Hartley guinea pigs are a frequently used model of OA because they develop OA spontaneously and display progressive degenerative changes that closely resemble the development of the disease in humans.
The most appropriate model for human T1D is the NOD mouse that develops the disease spontaneously and displays a similar pathology to humans [29].
