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These results suggest that, with prolonged culture, these cells may spontaneously acquire further genetic abnormalities that result in uncontrolled proliferation.
However, it has been reported that parasites can spontaneously acquire blasticidin resistance when exposed to sustained blasticidin treatment independent of the bsd-selectable marker [30].
Organisms that spontaneously acquire the ability to perform these operations increase their own metabolic rate (i.e. can use more CPU time) and thus tend to increase their own replication rate.
That prostate cancer can spontaneously acquire gain-of-function mutations in AR (rather than acquiring mutations that simply preclude inhibitor binding) underscores the special challenge in pharmacologically overcoming this mechanism of resistance.
When we excised Smad2 ex vivo in our IMEC cultures, a very small fraction of the population did spontaneously acquire a spindled appearance (data not shown), and the identity of this susceptible subpopulation will require further study.
MCF-10A breast epithelial cells, a subpopulation of which spontaneously acquire the CD44+/CD24- phenotype, were used to identify genes that are differentially expressed in CD44+/CD24- and CD44-/CD24+ CD44-/CD24+
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That means, new behaviourists say, that habits of good citizenship can no longer be easily or spontaneously acquired.
The idea was to track down and analyze dogs that had spontaneously acquired a similar condition.
We have previously reported that multi-cellular heteroaggregates comprising murine pancreatic α (αTC1.6) and β (MIN6-m9) cell lines spontaneously acquired islet-like architecture and displayed higher insulin secretion rates.
She is nearly run over as she confronts Will and Emma when they begin to go for a test drive in his spontaneously acquired Corvette.
Finally, we showed that such a phenotype was not innate but spontaneously acquired after diabetes onset, as the result of an adaptive response to the diabetic environment.
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