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To design a definitive QT trial attention must be given to the sources of QTc duration spontaneous variability.
Electrophysiological changes after pulsed radiation are within the limits of spontaneous variability under anesthesia, with only indirect evidence of possible retinal/cortical responses.
Spontaneous variability in the occurrence of paroxysmal arrhythmias has made it difficult to apply objective and quantitative methods to describe their clinical course.
Furthermore, spontaneous variability of RRI and SBP may result from numerous interfering mechanisms including both feedback and feedforward aspects which naturally characterize a closed-loop control system.
Because of these precautions, the changes observed during fluid challenge were well above the spontaneous variability of measurements.
An index near 1 indicates that the spontaneous variability is similar to the putative position-dependent modulation (i.e. no effect).
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The spontaneous quantifiable variability in our phenotype increases the sensitivity to differences in genetic variability.
Based on the above, we compared VILI with two ventilation approaches: (1) the conventional lung protective strategy where Vt and PEEP are controlled (6 ml/Kg and 5 cm H2O) and neuromuscular paralysis is used, or (2) a physiological approach with spontaneous breathing, variability and a liberated airway (without an imposed Vt and without PEEP).
This is in keeping with previous observations of a loss of spontaneous heart rate variability in patients with multiple organ dysfunction or sepsis [ 17].
Moreover, repeated BNP measurements in patients admitted to the hospital with ADHF could predict outcomes [ 24, 25], even if serial BNP levels are challenged by several factors (individual variability, spontaneous fluctuations) [ 26, 27].
Based on the concept that MV should mimic physiologically noisy breathing patterns, biologically variable or noisy MV was introduced, which attempted to mimic spontaneous breath-to-breath variability during volume-controlled MV [ 2].
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