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Latvakoski et al. proposed a communication architecture for spontaneous systems in [4] which integrates application-level spontaneous group communication and ad hoc networking together.
Latvakoski et al. [6] proposed a communication architecture for spontaneous systems which integrates application-level spontaneous group communication and ad-hoc networking altogether.
Active surveillances play supportive roles to spontaneous systems and do not aim to replace them.
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The thermodynamic results showed the negative value of the standard free energy ((Delta G^{0})) and standard enthalpy change ((Delta H^{0})) showing an exothermic and spontaneous system.
For example, a variety of studies [ 20– 24] have developed methods for detecting drug drug-adverse event associations using spontaneous reporting systems (SRSs) such as the US Foodrug drug-adversestration (FDA) AdveventEvent Reporting System (Fassociations
Spontaneous reporting systems for adverse drug reactions (ADRs), such as the yellow card system run by the Medicines and Healthcare products Regulatory Agency (MHRA) in the UK and the US Medwatch system, are handicapped by under-reporting and provide limited detail on individual cases.
Different analyses of international spontaneous reporting systems, known as disproportionality analyses (DAs), have highlighted the occurrence of ketoacidosis, amputations, acute renal failure and skin toxicity.
> Spontaneous reporting systems (SRSs) have long been the foundation of post-marketing drug safety surveillance [ 1].
Develop additional pharmacovigilance methods to complement data from spontaneous reporting systems.
Spontaneous reporting systems operate at the level of individual pharmaceutical companies and regional and national pharmacovigilance centres.
However, the limitations of spontaneous reporting systems (e.g., underreporting, the Weber-effect, reporting bias) should be taken into account.
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