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Spontaneous conversion seemed to occur after 90 h (Additional file 1: Figure S1).
However, this does not happen, because barriers to such a spontaneous conversion are provided by other factors.
Indeed, stimulating the Wnt pathway through L-Wnt3a ligands accelerated the spontaneous conversion of Scalow into the undifferentiated Scahigh cells (Supplementary Fig. 4a, b).
The protein may arise from a mutation incurred as the body ages or as a result of a spontaneous conversion in the protein's shape.
Spontaneous conversion from the native form of serpins into a more stable conformation, called the "latent" form, is restricted.
Because CommaDβ cells provided a model for studying the plasticity of mammary progenitors (Supplementary Fig. 2e), we wondered if miR-34a expression limits the spontaneous conversion of the more differentiated Scalow cells into the early progenitor state (Scahigh).
In the absence of such aerosols, the spontaneous conversion of water vapour into liquid water or ice crystals requires conditions with relative humidities much greater than 100percentt, with respect to a flat surface of H2O.
Acute ablation of miR-34a in a mammary progenitor cell line (CommaDβ) elicited the spontaneous conversion of more differentiated cells (Scalow) towards an undifferentiated/MaSC-like state (Scahigh), indicating that miR-34a is implicated in cell commitment and differentiation.
Spontaneous conversion of beta-amyloid peptide (Aβ) from soluble monomer to insoluble fibril may underlie the neurodegeneration associated with Alzheimer's disease.
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"Under the heading 'Spontaneous Conversion' I found at Number 11 a 'Simon Hatey' who was from 'Yudstock'.
15 18 In this patient with chronic bronchitis, 'spontaneous' conversion to SR without the need for administration of amiodarone or ECV proved to be an effective route and underlines the value of an integrative approach.
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