Although Rab25-deficient mice do not develop spontaneous colon tumours, breeding of ApcMin mice onto the Rab25-deficient background induces a marked increase in tumours, and crossing of Smad3+/− mice onto the Rab25 knockout background yields large invasive tumours.
A starting research question might be something like, "How are women represented during the silver age of American comic book publishing?" or "What are the implications of spontaneous genetic mutation during breeding in drosophilia, and what effect might this have on cancer research?".
Their spontaneous behavior, defined as movement, breeding behavior, and total activity, as well as their habits were then observed at 2 and 4 months.
SNS-S1P1−/− mice were viable and did not show any obvious deficits in spontaneous behavior, motor capabilities or breeding.
Moreover, we found for the first time that some old individuals manifest a spontaneous hyperlipidemia in our close breeding population.
Despite the outstanding importance of genetics-based breeding applied to spontaneous mutations and conventional hybrids, molecular and genomic tools are expected to develop their great potential for crop improvement through functional genetics analysis, involving gene and function discovery and genome modification.
Vegetative propagation and dissemination, spontaneous events of hybridization among cultivars, breeding with local wild plants and likely secondary domestication events generated the pattern of admixture that is observed in current cultivars [ 4]–[ 9].
These included JI281, WL1771, the argenteum mutant [also a spontaneous mutation that emerged in a breeding line belonging to L.G. Cruger, with an unknown background (Marx 1982)] and the cultivars Cameor, Champagne, Kaliski, Torsdag (Hobart Line 107) and Virtus.
The original wilty line resulted from a spontaneous mutation that emerged in a breeding line belonging to L.G. Cruger from Del Monte Corporation, San Lenadro, CA, and was later sent to Prof. G.A. Marx in the early 1970s (Marx 1976).
Several spontaneous TGMS mutants have been independently identified in breeding programs; more TGMS lines were selected in the progenies derived from NK58S (Si et al. [2012]).
