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Femoral stem revision with a locked stem after total hip arthroplasties treats severe bone defects by favoring spontaneous bone reconstruction.
Although implant primary stability and spontaneous bone graft after immediate implantation are important factors for high success rates and esthetic outcomes, the relationship between them has not been sufficiently evaluated.
The PFMR® proximal femoral modular reconstruction implant (Protek, Sulzer Orthopedics, Switzerland) is a straight modular stem in sanded titanium with press-fit anchorage, intended to achieve spontaneous bone reconstruction following Wagner's principle.
Orthotopic tumors formed by 4T1 cells have been shown to induce spontaneous bone metastasis [41].
In our study, we observed that mice bearing orthotopic 4T1 tumors showed an increased incidence of spontaneous bone metastasis as well as greater bone tumor burden after doxorubicin treatment in comparison to the placebo treatment.
To analyze spontaneous bone metastasis in the 4T1 model, bone tissues (tibia and femora) were fixed in 10% neutral buffered formalin (Fisher Scientific) for 48 hours at room temperature, decalcified in 10% EDTA and embedded in paraffin.
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This study evaluated the effect of an experimental carcinogenic, 4-Nitroquinoline 1-oxide (4NQO), in the spontaneous alveolar bone loss (ABL) in an animal model.
OSA is also the most common spontaneous primary bone tumor of dogs, estimated to affect greater than 8,000 dogs annually in the United States [ 2].
They didn't know David Bowie either, or Robin Williams, yet the reactions to their deaths were spontaneous, emotional, bone-felt.
However, to the best of our knowledge, there is currently no immune competent spontaneous BC-bone metastasis model available.
Moreover, we showed the capability of IL-7 to stimulate spontaneous osteoclastogenesis of bone metastatic patients and to induce osteoclastogenesis in cancer patients without bone involvement.
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