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We analyzed the ClinicalTrials.gov database contents as of June 2011, comparing interventions, medical conditions, and trial characteristics by sponsor type.
In addition, HKS principal investigators will be required to confirm that their HKS annual report is updated as applicable prior to the submission of new sponsor proposals, regardless of sponsor type (U.S. government, private foundation, etc). Additional disclosure requirements may be imposed on recipients of PHS grants under federal rules.
We tested for interaction between sponsor type and REC.
For product information and supporting documentation, the interaction between sponsor type and REC was p < .05.05
We controlled for the REC that reviewed the protocol by including both sponsor type and REC as predictors in the model, and tested for interaction between sponsor type and REC.
The shortcomings of protocols that are identified during REC review have not been compared by sponsor type though.
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Finally, within shareholder proposals, we rank sponsor types.
Differences between sponsor types are not statistically significant with the exception of pension funds and individual activists: pension fund sponsored proposals are more important than those sponsored by activists.
The publication rate for the Chinese trials sponsored by industry was the lowest of the four sponsor types at 23.8%, while the publication rate for Chinese trials sponsored by universities was the highest, at 40.7% (table 2).
To examine the associations between trial characteristics and publication rate, we calculated the publication rate for trials at different stages, and with various sponsor types, study designs, and intervention types.
The trial stage was categorized as completed, ongoing, terminated, or suspended; sponsor types were industry, central or local government body, hospital, or university; study designs were observational, interventional, randomized, and non-randomized; interventions were biological, behavioral, dietary supplement, device, procedure, drug, gene transfer, other, and not specified.
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