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There is often no alternative to the use of gemtuzumab ozogamicin, however, splitting dose (3 mg/m) probably allows a decrease of the SOS/VOD risk.
With the increasing of the total amount of drug, the PTA increased accordingly in both single doses and 2 splitting dose regimens.
As the third step, gliclazide-MR should be uptitrated to a maximum dose of 120 mg per day and metformin to 2,550 mg per day with a splitting dose.
However, the same daily amount of CEQ administered once-daily or twice-daily, such as 1 mg/kg/12 h and 2 mg/kg/24 h, resulted in different PTAs (76.87% and 44.79%, respectively) implying that splitting dose would reach higher PTA than a single dose administration.
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In support for this recommendation, preclinical studies have shown that splitting pirfenidone doses partially alleviates pirfenidone's inhibitory effect on gastric motility in animal models (InterMune data on file).
When a study had two metformin arms of different doses, we included both in the analysis and present results ordered by dose, splitting the comparator group into two to avoid covariance problems (9).
Because drugs frequently cost about the same at various strengths, some experts recommend buying higher doses and splitting the pills.
In studies with similar clinical indications in which contrast medium administration was not critical, the dose effect of splitting long image ranges into two separate helical acquisitions was variable.
Use a maul or splitting wedges to split hardwood.
To determine the weight variation and calculated dosing variability of tablet fragments upon splitting unscored cyclobenzaprine hydrochloride 10 mg tablets using two common tablet splitting devices.
Adjusting for dosage may be performed by including it as a continuous determinant in mg/day or categorized, for instance by splitting current use as: current use with >1 defined daily dose (DDD); current use with ≤1 DDD.
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