However, neither of these approaches has the ability to correct split or collapsed loci either because they do not have dense enough marker information within such loci (RAD-tags) or do not contain genetic information (optical mapping).
A two-channel or split-window algorithm designed to correct for atmospheric conditions was applied to thermal images taken by the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) of Lake Yugama on Kusatsu Shirane volcano in Japan in order to measure the temperature of its crater lake.
Despite a clear political will (as well on the national as on the European level) to correct the modal split, the trend appears to be difficult to stop, given the difference in infrastructure costs and the difficulties of alternative modes to adapt to the current trends in production systems.
Interestingly, in this paper by McKusick it is described how causative genetic loci may be a way to partially address this in that genetic information will be a means to correct for excessive splitting, but this was argued on the bases of Mendelian diseases.
RPGC was able to correct 95% of these split loci and was also able to confirm that an equal number of highly similar pairs of loci with reduced read-depth were in fact true paralogs (see next paragraph).
After processing by PLGS, the so-called Exact Mass and Retention Time (EMRT) table was exported and reclustered using the PACP tool [ 59] to correct potential misalignments and split peak detection errors.
To correct for cells potentially split in the z-dimension, all neurons in focus at the top border of the sections were excluded (optical dissector; Hyman et al., 1998; Hatton & Von Bartheld, 1999).
To correct for this issue, scaffolds were split (always at contig boundaries) in order to assign genes to the appropriate homologous chromosome (Additional file 2).
The selection of a pruned sub-tree can be based on a re-sampling technique (cross-validation) to correct for over-optimism due to split point optimization [ 6].
Manual editing was used to merge EST sequences and gene predictions, to correct frameshifts, and to fuse one gene split across two contigs.
