This resting state questionnaire (ReSQ) consists of 62 items organized by five main types of mental activity: visual mental imagery (IMAG); inner language (LANG), split into two subtypes, inner speech (SPEE) and auditory mental imagery (AUDI); somatosensory awareness (SOMA); inner musical experience (MUSI); and mental manipulation of numbers (NUMB).
The infection responses were split into two subtypes, i.e., Upper vs. Mock, and Lower vs. Mock.
Among the predominant clusters, two SIT signatures (SIT459, SIT204) were found to be prevalent and each split into two subtypes.
In the second iteration, Type 1 was split into three subtypes, denoted as Subtypes 1.1, 1.2, and 1.3, whilst application of iNMF to Type 2 led to the identification of Subtypes 2.1 and 2.2 (Table 2 and Figure 3).
While the O group was further divided into OA and OB subtypes, the G group was split into four subtypes, showing hierarchically-nested relationship designated as GA1, GA2, GB1 and GB2.
Subsequently, Type 1 was split into three subtypes, 1.1, 1.2, and 1.3 that are defined by up-regulation of 439 probe sets (287 genes) for Subtype 1.1, 193 probe sets (141 genes) for Subtype 1.2, and 352 probe sets (219 genes) for Subtype 1.3 (Additional file 4: Table S7, Additional file 5: Table S8 and Additional file 6: Table S9).
Here, for the first time, we applied voxel-based morphometry (VBM) to study grey matter volume (GMV) differences in a relatively large sample (n = 46) of dyslexic children split into three subtypes based on the cognitive deficits: phonological, rapid naming, magnocellular/dorsal, and auditory attention shifting.
In a recent VBM study by Jednoróg et al. (2014) with 46 dyslexic and 35 control children (mean age 10 years), the dyslexic children were split into three subtypes based on various cognitive deficits (phonological, rapid naming, magnocellular/dorsal, auditory attention shifting).
Most research arbitrarily splits patients into two subtypes based on a cut-off point at 65 years of age, namely early-onset and late-onset AD (EoAD and LoAD, respectively).
Relational processes can be subdivided into two subtypes: attributive subtype (7.59 %), and identifying subtype (2.02 %).
In 1987 this was changed to ADHD in the DSM-III-R and the DSM-IV in 1994 split the diagnosis into three subtypes, ADHD inattentive type, ADHD hyperactive-impulsive type and ADHD combined type.
