The arm that received Cisplatin and 5FU had a split course RT regimen.
CRT consisted in bolus 5-FU and radiotherapy of 40 Gy in a split course technique.
Targeting was based on new, separate CT scans for each split course.
The addition of chemotherapy can also help to compensate possible negative effects of split course regimens.
Despite promising data the significance of split course RCT in SCCHN is unclear.
Split course radiotherapy in standard fractionation schemes is known to be disadvantageous for patients with head and neck cancer.
The chemoradiation consisted of bolus 5-fluorouracil (5-FU) and split course radiation to a total dose of 40 Gy.
Split course radiotherapy in standard fractionation schemes is known to be detrimental for head and neck cancer patients.
In the present trial, we used an early split course twice daily radiation therapy in combination with chemotherapy.
Ernst-Stecken et al. recently reported encouraging results in a phase II study on hyperfractionated accelerated split course radiochemotherapy in head and neck cancer [ 7].
