Sentence examples for split alignment from inspiring English sources

When preliminary urban routes were laid out in 1955, a split alignment was chosen to serve both cities equally.

We measured the percentage of queries with a split alignment that verified the correct SV breakpoint (within 5 bases) and the total number of verified breakpoints (Fig. 3A).

Also, although the pipeline that was built around SPANNER was able to utilize the SR signal, its split alignment algorithm is only compatible with reads collected using the now defunct 454 sequencing technology.

The authors detected mis-assemblies by finding contigs that have a split alignment to the optical consensus map, then selected the assemblies with highest contiguity (i.e., with the most resolved repeats), but which did not exhibit any mis-assemblies with respect to the optical map.

Even (split) alignment based approaches may fail to provide accurate breakpoints, as accurate gap placement in alignments has remained an algorithmic challenge in bioinformatics (see e.g. [ 26] for a description of effects such as gap annihilation, gap wander and so on).

MSAs that did not meet these criteria were manually inspected to evaluate further manual editing (split alignments).

We show below that YAHA's OQC algorithm is better at discovering SV events than the heuristic approach used by BWA-SW for finding split alignments.

This approach allows us to report multiple overlap alignments (including split alignments) for an experimental map while using the q-value analysis, as before, to report all alignments with q≤0.01.

For 15,773 pig conreads, we observe split alignments mapping to different loci on the cow genome [see Additional file 1, Figure S3 for the number of loci per conread].

Reads that could not be aligned were mapped again to hg19 using LAST (s2 –l11 –d30 –q3 –e30), which excels in reporting split alignments found for translocations and, for RC-seq, where one end of the assembled read contig maps to one location on the genome and the other end maps elsewhere.

We applied a sophisticated genome-versus-genome comparison strategy that efficiently integrates the split-alignment algorithm from LAST [ 16] and the align-gap-excise algorithm from AGE [ 17], and subsequently implement an efficient method to initially identify various forms of structural variation and novel sequence from the assembly-versus-assembly alignment.