Sentence examples for splicing function from inspiring English sources
This result demonstrates that a single deletion event removing all of the HEG is compatible with retaining splicing function (that is, the HEG and splicing functions are separate).
Furthermore, animal proteins with similar domain organization such as human Tra2a and Trab cannot substitute for the essential splicing function of SR proteins [22].
Also alterations in splicing function has been implicated in many diseases, including neuropathological conditions such as Alzheimer disease, cystic fibrosis, defects in growth and development, and many human cancers [27].
Recently it has been shown that human satellite III transcripts, induced by stress, recruit the splicing factors to nuclear stress granules regulating in this way splicing function [9], [10].
For comparison, we also examined the mRNA levels of a house keeping gene, β-2-microglobulin and a single exon gene Histone 4. These data further demonstrate that RP18 mutation does not cause a major defect in splicing function, nor does it affect the splicing of retina-specific and house-keeping genes (Table 2).
Subsequently, the MRS1 lost its splicing function, which also seems to have been neutral.
Parallel changes in matK associated with intron loss in two independent lineages of parasitic plants indicate that reduction of generalist splicing requirements may cause the protein to undergo adaptive changes to specialize on remaining intron splicing functions.
An interesting question is whether the splicing functions of RBM4 are subject to stress-regulation.
This 'model intron' will shed light on the minimal requirement elements of recognition used for conventional splicing functioning.
For example, sxl was first shown to encode a product with pre-mRNA splicing functions, acting on sxl and tra pre-mRNAs [reviewed in [ 7, 53]].
Thanks to their small size, our 'model introns' will help identify the basic and crucial minimal requirement elements of recognition used by the cell for conventional splicing functioning.
