Gross pathologies observed in our cohort of Men1+/+: Trp53+/− and Men1+/+: Trp53−/− animals were consistent with published descriptions of other Trp53 knockouts, most commonly including lymph node and spleen pathologies, consistent with the frequent lymphoma observed previously by others.
Chi-square tests revealed that the prevalence of liver and spleen morbidity (pathology characteristics 1 to 7 in Figure 1) did not differ significantly in children with S. mansoni infection only compared with co-infected children.
Overall, in the guinea pig aerosol model, the TAMU H37Rv strain, obtained from the ATCC, propagated in Middlebrook broth and frozen, was either comparable or more virulent than the mouse-passaged JHU strain when evaluated in terms of lung CFU counts, spleen CFU counts, or lung pathology.
This was associated with inflammatory pathology in the lungs, spleen, and brain as well as morbidity and mortality.
Mean pathology scores of liver, spleen, kidney and lower lobe of the right lung of the two animals of group B that eventually survived were 0.5, 0, 1.5 and 0 respectively.
Schistosome infection may cause severe pathology of the liver, spleen, kidneys, bladder and urinogenital tract, and is responsible for high morbidity in endemic areas with an estimated loss of 1.76 million DALYs [ 1].
P of comparisons to group A: a0.016, b0.049 Bacterial loads and pathology scores of the infected kidney, liver, spleen and lower lobe of the right lung when death occurred are shown in Table 3 and in Figure 3. Negative correlations were found between bacterial load and pathology scores of spleen of group B (r: -0.884, p: 0.047).
More than 90% of those 273 chemicals caused pathologies in the liver, kidney, thyroid, lung, testis, or spleen.
Following sacrifice, multiple tissues (lungs, spleen, liver, kidneys, heart, stomach, intestine, testes, and ovary) were examined using standard toxicological pathology criteria and no toxicity was associated with fisetin treatment.
