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Reduction of spleen size using ultrasound or computed tomography can be used to detect hyposplenia, but it is unclear whether non-functional imaging reveals useful information about risk for severe infections or spleen function [ 15].
Excessive blood cell destruction caused by increased spleen function is important evidence of hypersplenism.
60 180 mg/kg daily gavage for mice was conducted for 7 weeks consecutively, and the result showed no clear influence on the hemogram, liver and spleen function.
Further, does the spleen function as a monocyte reservoir for mobilization during periods of acute inflammation as has been observed in mice [45]?
We conducted a collaborative pilot trial of hydroxyurea in infants with SCA to assess its (1) feasibility of administration, (2) toxicity, (3) hematologic effects, and (4) effect on spleen function.
However, compromised spleen function has not been reported after PRRT.
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The teleost spleen functions as a major secondary immune organ, as in mammalian species.
Whether this is also an effect of the b2m KD is difficult to determine, since this cell fraction includes a variety of cell types, from B cells to macrophages and other leukocytes, and can vary considerably from one individual to another, presumably because in Xenopus the spleen functions both as primary and secondary lymphoid organ.
Establishing the diagnosis of functional hyposplenia is based on the spleen filtering function of radiolabelled isotopes or by detection of morphological erythrocyte abnormalities.
Importantly, all seven of the genes evaluated in the spleen that function in protein folding or in the endosome/lysosome system showed increased expression in scrapie-infected mice relative to mock-infected mice.
Ranking these terms in order of statistical significance (Table 1) revealed that in the spleen, biological functions including lysosome, phagosome, cell adhesion, and basic metabolic function (carbohydrate, amino sugar, and nucleotide sugar) were most significantly impacted.
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