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Discover Ludwig"spite of this" is correct and can be used in written English.
You can use "spite of this" when you want to express something in spite or despite of something else. For example: "Despite having taken the necessary precautions, the project was a failure; spite of this, we still managed to learn valuable lessons."
Exact(60)
In spite of this, I remain optimistic.
In spite of this they are becoming poorer.
In spite of this, it was more disturbing.
In spite of this, the WMC has endorsed the bill.
In spite of this, not one indictment was ever issued.
In spite of this, the acting is impressive.
In spite of this modernization, trade had changed.
In spite of this I have an ethical dilemma.
In spite of this, he goes to America.
But in spite of this, I do like her.
(In spite of this, Sewell's loyalty to Blunt never failed).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com