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In spite of improving the conversion yield by this method, the existence of a few technical difficulties during the enzyme-catalyzed esterification of phenolic acids has been noticed such as their low solubility in the presence of some organic solvent media (e.g. in hexane) where the enzyme is active or reversed behavior in other solvents (e.g. DMSO).
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In spite of improved technology capabilities, the introduction of what is often called "precision medicine" or "personalized medicine" in hospital routine laboratories has been slower than expected, mainly for two reasons; the degree of automation the interpretation of data.
So in spite of their improving fortunes, the emerging middle classes of Asia, Africa and Latin America (and even the struggling lower middle classes of North America and Europe) could well have to do without.
In spite of the improving costs of initial investment, barriers to EHR adoption remain [ 6].
The poverty level has remained above 25% of the population in both countries in spite of the improving overall economic conditions.
In spite of increasingly improved treatment options breast cancer remains a severe life threatening disease.
Many South Koreans, nursing centuries of resentment against the Japanese in spite of the improved relationship of the last two decades, have been marching, protesting and even rioting in recent weeks in opposition to President Roh's visit to Tokyo this week.
In spite of the improved performance of super-elastic damper, the available variant of SMA(s) is quite expensive to limit their applicability.
In spite of the improved prediction of the composite TWS annual cycle, multi-decadal hydrological trends for the MSRB produced by the CMIP5 models vary.
In spite of the improved BC survival rate due to endocrine therapies that modulate ER action, resistance to treatment is a major clinical concern.
In spite of the improved prognosis when treated, DPB currently has no known cure.
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CEO of Professional Science Editing for Scientists @ prosciediting.com