In spite of the depth of the attachment that I feel to the city in which I have built my career, I am always aware that Milan does have its shortcomings and that it lies at times in thrall to a prevailing mood of melancholy, which has perhaps altered its character and diminished its sense of optimism, its capacity to think big and retain the confidence to accomplish its ambitions.
On a technical level, in spite of the depth possible with 454 FLX platform, the Sanger and pyro-based sequencing methodologies were complementary as each method generated sequences unique to each platform.
Two of the seven trials included in the meta-analysis of OS could not be included in our analysis of surrogacy because the definition of PFS could not be ascertained reliably in spite of in-depth review of the case report forms.
Therefore, in spite of a uniform depth of the thermal LAB, lateral variations in temperature evolve in the upper part of the lithospheric mantle and the lower part of the crust illustrated by upward-curved isotherms in Fig. 7b.
The self-ion irradiation uniformly improves the crystal quality of the irradiated layer up to a depth of ∼ 200 nm, rather close to the depth corresponding to the end of range of ions, in spite of the non-uniform depth distribution of displaced Ag atoms.
However, in spite of relatively low read depths of Black Angus and Holstein bulls, 97.4% and 97.7% of the reference genome was covered by the sequenced reads at the minimum read depth of 1, respectively (Additional file 3), higher than the 93% coverage with 15.8-fold mapping depth reported in Kuchinoshima-Ushi [ 7].
In spite of its extensiveness and in depth analysis some of the Outlook assumptions and conclusions need careful analysis and review.
On the other hand, there is no significant slip at shallow depth in spite of the fact that the plate interface is thought to be fully locked there, may be suggesting that there still remains a potential of fault slip.
In spite of these impediments, the sequence depth and ease of data generation indicate RNA sequencing provides a reliable resource for validation and improvement of structural gene models.
In spite of the different locations and depth of the sampling sites, the two A. australica strains form a highly homogeneous clade with an average nucleotide identity (ANI) of 98.6%.
Characters are types, splendidly rendered by the company (in spite of dodgy accents), but lacking dramatic depth.
