Sentence examples for spindle in which from inspiring English sources

Monastrol can efficiently be removed from cell, which allows the formation of a bipolar spindle in which full chromosome alignment requires correction of the improper attachments by Aurora B [30], [31].

In some cases, however, we observed multipolar spindles (phenotype "3"), pseudoanaphase with scattered chromosomes along the elongated spindle (phenotype "4"), or cells with a bipolar spindle in which a number of chromosomes (from one to five) had not congressed yet to the metaphase plate (phenotype "5", Figure 6B).

We also observed multipolar spindles containing discrete aggregates of chromatin and unfocused spindles in which the chromatin was fragmented in small aggregates.

Despite these differences, both mutants display similar monopolar spindles, in which only the mother SPB could nucleate spindle microtubules, albeit with reduced intensity.

Quantification of immunofluorescence intensity revealed that compared to stage 3 spindles in which kif2a localized weakly to kinetochores and spindle poles, increased amounts of kif2a homogeneously localized to stage 8 extract spindles, with a slight enrichment at spindle poles.

Monopolar spindles in which a single SPB nucleates nuclear microtubules also were seen in 7% (n = 102) of sec66 ∆ cells compared to <1% (n = 105) of wild-type cells.

The lack of alignment to any specific type of cell-cell junction argues against a simple model of spindle positioning in which the spindle tethers level with the junction.

Activation of the budding yeast Cdc14-Cdh1 pathway requires a specific spindle orientation, in which one of the spindle poles is located in the daughter bud [49].

Our results support a model of spindle assembly in which microtubule polymerization dynamics are not spatially regulated, and the proper organization of microtubules in the spindle is determined by nonuniform microtubule nucleation and the local sorting of microtubules by transport.

This result shows that both pcp1 mutants exhibited compromised nucleating activities of spindle microtubules, in which only the mother SPB manages to retain nucleation capability to some extent.

To test whether PEFs are required to satisfy the SAC in SMUGs, independently of chromosome bi-orientation and the establishment of merotelic attachments, we investigated the duration of mitosis in Nod-depleted cells with a monopolar spindle configuration (in which only monotelic attachments can be established), after co-depletion of the Kinesin-5 protein Klp61F by RNAi (Cane et al., 2013).