The overall morphology of persisting muscle spindles was unchanged in Bace1−/− mice at P0, but postnatal muscle spindle growth was impaired.
Interestingly, Aurora B is localized at centrosomes during mitosis and may influence spindle growth from the centrosome to the kinetochore during mitosis, similar to LOC375190, resulting in defects in chromosome segregation and/or premature mitotic exit [ 57].
The cap size also increases with time in myosin inhibited embryos in sync with spindle length growth (Fig. 4B).
The myoepithelial carcinomas resemble sarcomas by having a predominantly spindle cell growth pattern [ 20, 23].
TACC3, in complex with the Ch-Tog protein, is essential in spindle microtubule growth and stability [ 14, 49]; hence, alteration of TACC3 localization following MK-0457 treatment could explain, at least in part, the aberrant spindle formation in TT cells.
EGR3 encodes a zinc finger transcription factor and plays important roles in cellular growth, environmental stimuli, muscle-spindle development and neuronal development [ 29].
Several studies have been reported with different designs to control or monitor spindle's thermal growth with limited results.
The thermal growth spindle error is compensated for real time using a fast tool servo driven by a piezoelectric actuator along with a capacitive displacement sensor.
Down-regulation experiments using RNA-interference has proven that Ncl is essential for cell division, given that absence of Ncl results in prolonged cell cycle with misaligned chromosomes, defects in spindle organization [18], growth arrest and increased apoptosis [19].
In addition, we show that SNAI2/Slug activates a program of phenotypic changes in human glioblastoma cells that includes increased spindle morphology, vasculogenesis, growth and invasion.
Dephosphorylation of stathminS38 led to an inhibition of cells at G2/M phase, lack of spindle assembly, and growth inhibition [ 20, 21].
