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This release experiment was carried out in the presence of different chemicals to assess their effects on the mitotic spindle functions.
This motor protein plays an essential role in nuclear motility and mitotic spindle functions [ 7, 11].
Almost all of these genes were shown to affect genomic stability by impairing homologous recombination, sister chromatid cohesion, or mitotic spindle functions.
Genes with kinetochore and other mitotic functions also emerge, although they are primarily connected to CIN cancer genes with cohesion and spindle functions.
The data presented here indicate that one unwanted side effect of a long-term inhibition of Bace1 in adults might be disrupted muscle spindle functions, which are expected to impair coordinated movement.
The diverse actions of VFL on microtubules are likely to produce different effects on mitotic spindle functions leading to modifications of cell cycle progression and cell killing (Ngan et al, 2000).
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In general, DTX-loaded NP induce mitotic arrest by the release of drug which produces unstable microtubule, interfering with the mitotic spindle function, thereby arresting the cells in the G2/M phase of mitosis [25].
In addition, the review will endeavor to point out some kinesins that have been studied extensively but which still lack sufficient molecular underpinnings to fully predict their contribution to spindle function.
Overall, as architectural features of different spindles are elucidated, the available comparative genomic data should provide structural and mechanistic insight into how a spindle is built, how dynamic interactions lead to a steady-state structure, and how spindle function is disrupted in disease.
Otherwise, meiotic and mitotic spindle function appeared normal.
EGFP-hZW10 expressing cells were pretreated with various inhibitors of spindle function followed by NDGA in live cells.
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