Here we show that the conserved internal loop [ 6, 7] of fission yeast Ndc80 directly binds the Dis1/TOG microtubule-associated protein [ 8 10], thereby coupling spindle microtubule dynamics with kinetochore capture.
To ensure the proper inheritance of localized molecules, the position and orientation of the mitotic spindle must be coupled to overall cell polarity.
Spindle dynamics are coupled to other mitotic events, for example chromosome attachment, anchorage of aster microtubules to the cell cortex and positioning of the cleavage furrow (Neujahr et al., 1998; Niewöhner et al., 1997).
Mitosis onset is characterized by a burst of Moe activation and the spatiotemporal regulation of Moe activity plays an important role in coupling cell shape control and spindle morphogenesis during mitosis [7], [8].
Thus, while coupling DNA damage and repair to the spindle assembly checkpoint has been observed [7], [8], it is not clear whether these mechanisms are related to the sensing of DNA damage during anaphase.
The tool tip FRF is then predicted by coupling the Timoshenko beam based tool-holder to spindle.
In Drosophila, that role is fulfilled by Inscuteable (Insc), which functions by coupling the LGN (Pins) complex with the Par complex [ 37,4,38] to direct LGN apical localization and determine orientation of the spindle.
This paper investigates the stability of a disk-spindle system supported by coupled journal and thrust bearings considering the five degrees of freedom of a rotor-bearing system.
Overall, our data suggest that spindle width and length are coupled anisotropically.
Coupling spindle pole broadening to anaphase onset could potentially serve a dual purpose in regulating chromosome dynamics in the context of our model.
