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Nevertheless, a spinal diffusion of FG towards the contralateral side and/or the central aspect of the cord was observed.
For the first time, spinal diffusion tensor imaging (DTI) and electrophysiological recordings were coupled to evaluate the anatomofunctional properties of sensory pathways in humans.
The study aim was to investigate the anatomofunctional properties of sensory pathways in patients with ALS, combining spinal diffusion tensor imaging (DTI) and somatosensory evoked potentials (SEPs).
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Ghost artifacts are a major contributor to degradation of spinal cord diffusion tensor images.
There are several diseases that lead to either local or general changes in spinal cord water diffusion.
To permit visualization and characterization of BDNF's diffusion through spinal cord tissue, Rhodamine was conjugated to BDNF.
Moreover, the relevant effect of the cerebrospinal fluid flux dynamics on the drug diffusion in the spinal cord tissue was here revealed for the first time: an oriented delivery of the released molecules in the spinal cord tract caudally to the gel site is demonstrated, thus suggesting a more efficient gel positioning rostrally to the lesion.
As water molecules within the spinal cord prefer a craniocaudal diffusion direction along white matter fibers they are illustrated mainly in blue color.
Brain systems controlling behavior may be influenced by peripheral inflammation and cytokines via a set of discrete routes, including activation of vagus nerve or spinal cord interoceptive afferents, passive diffusion of cytokines into cerebrospinal fluid in regions that lack a blood-brain barrier, or active transport across the brain endothelium via cytokine-specific transport molecules (1).
It is a first step towards in vivo characterization of the healthy and injured human spinal cord using high angular resolution diffusion imaging and QBI.
After analyzing the specificities of formulations designed for spinal drug delivery, applications referring to diffusion modifiers or depot dosage forms are then overviewed.
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