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Is it correct that spiking is generated in the model by the standard M-L equations and that the added HH Na and K currents are strictly subthreshold; i.e., they do not produce spikes?
Additionally, guidance from AOAC on methods validation indicates that spiking is not a desirable method to assess method accuracy as spiking solutions tend to be easily extractable hence the choice of the NIST standard to evaluate the method.
Spiking is meant to stop the clock in a hurry-up situation.
Consequently, any spiking is likely to pose significant irremediable long-term danger.
But whether speculation has really been responsible for prices spiking is a controversial issue.
The poster child for drug-price spiking is Martin Shkreli, the loathsome chief executive of Turing Pharmaceuticals.
Another myth is that spiking is only a crime if coupled with assault: drink-spiking carries a maximum 10-year sentence even if no added sexual assault or theft takes place.
While the idea of malicious drink spiking is understandably terrifying, the evidence suggests that it is exceptionally uncommon and that these products instil a false sense of security and a skewed perception of risk.
The threshold manifold for trajectory spiking is indicated (orange dashed).
This inhibition-induced spiking is a feature of many thalamo-cortical neurons (Izhikevich [17]).
When (z = 0) (Fig. 1A) spiking is much faster than when (z = 0.7) (Fig. 1C).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com