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When the spike pair was over, the presynaptic or postsynaptic current I 2 was measured after waiting for 5 min.
Food TV chef Kelsey and Top Chef star Spike pair up on a show where each use similar ingredients to create dishes-kind of like a face-off of recipes.
The actual amount of LTP for a given spike pair is given by their exact spike times through the potentiation curve P Δt), where Δt≥0.
To clarify, the algorithm annotation of P, e and r spikes were not manually corrected unless a pump (i.e. an E-R spike pair) with which they were associated had been incorrectly identified.
On the basis of this observation, they proposed a model in which the synaptic weight change is not just dependent on the timing of a spike pair, but also on the efficacy of the spikes.
For example, the mean instantaneous firing frequency of the first spike pair elicited with a 150-pA current injection was 59 ± 16 Hz in WT animals and 122 ± 23 Hz in DISC1tr mice, a > 100% difference, whereas the equivalent frequency difference with a 300-pA stimulus was only ˜25%.
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Is LTP/LTD really dependent on spike pairing?
This prediction is independent of whether the spike pairing scheme is all-to-all or nearest neighbor (see Sect. 4.1.2).
An additional confounding factor is that the timing interval used in the spike pairing protocol varies considerably across the data.
Firstly, from our three-dimensional rate maps we generate a representative number of spike pairs through a Poisson process to construct the distribution of distances.
Depending on the definition of the trace dynamics (accumulating or saturating, see Sect. 2.3), different spike pairing schemes can be realized.
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