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The drug agglomerates were prepared by the method of spherical agglomeration in liquid with control of the particle size of the primary drug crystal, agglomerates and mechanical strength of agglomerates by changing the agitation speed of the agglomeration system before (5°C-1000 r.p.m).
In order to prepare a dry powder inhalation (DPI) formulation for steroid KSR-592, we designed agglomerates consisting of fine primary drug particles suitable for inhalation by the spherical agglomeration method.
Spherical agglomeration has the potential to dramatically simplify downstream processing, and improves the handling of difficult, needle-shaped crystals.
The spherical agglomeration of calcite suspension occurs at high surfactant concentrations (3 10−3 kmol/m3).
Particle design via spherical agglomeration is a size enlargement technique used in various bulk and fine chemical industries, with recent interest extending into pharmaceuticals, in which an immiscible bridging liquid is added to agglomerate crystals prior to deliquoring.
It was found that the particle size of primary crystals increased until the dispersing medium was saturated with the bridging liquid introduced to the system, whereas the spherical agglomeration of primary crystals continued even after the saturation.
Similar(51)
Separation of nearly spherical agglomerations of nuclei may fail in some cases.
All graphene sheets were buried in the spherical agglomerates composed of primitive particles through the second agglomeration.
The secondary agglomerates results of the agglomeration of the spherical particles.
Moreover, hierarchical structure with spherical morphology could reduce agglomeration during electrochemical cycling, which will result in the long cycling stability.
In all of the cases, a spherical morphology and no agglomeration were observed.
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