As for the element of truth which is obscurely at work in this distinction between logical form and metaphorical form, dialectic and rhetoric, we may detect in it the need of a science of aesthetics side by side with that of logic; but it was a mistake to try to distinguish the two sciences within the sphere of expression which belongs to one of them alone.
Indeed the word Vorstellung has an important but shifting philosophical pedigree in German idealism: for Kant, it is the basis of concepts and intuitions (Anschauungen); for Hegel, it is the preliminary form of the concept before it is specified and developed as idea, associated with feelings and hence its proper sphere of expression is art.
These data confirmed that PROM1/CD133+ cells have CSC-like properties, such as generation of spheres, high expression of stemness-associated genes, and high resistance to chemotherapeutic drugs and PDT.
Finally, to further support possible differentiation of cell derived from spheres, expression of epithelial differentiation markers was examined demonstrating positivity for cytokeratin AE1/3 in all differentiated spheroids (data not shown).
The two cell types showed all known hallmarks of TICs, including tumor growth from very low cell numbers, sphere formation, expression of a panel of markers and, in one case, of ALDH activity.
The AT13387 treatment effectively inhibited the formation of tumor spheres, reduced the expression of CSC markers, and suppressed in vivo tumorigenicity of C666-1 cells.
In our murine system, Snail1 inhibition resulted in loss of tumor-sphere formation, decreased expression of CD44 and Nanog, and decreased tumor growth.
A man who then dismantles the structures of civil society, the press, the means of expression, to expand his authoritarianism to every sphere of life.
The increased level of stemness in NeuTL and MCF7 spheres documented by expression of specific markers [ 7, 30- 34] is consistent with our recent results using microarray chip approach [ 35].
Earlier studies have also identified putative brain tumour stem cells (BTSCs) on the basis of their ability to form tumour spheres and the expression of neural stem cell marker CD133 (Singh et al, 2003; Singh et al, 2004).
