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The analytic solution has five parameters: signal (true activity within the sphere), background level, FWHM of the PSF, and the radius as well as the (cold) wall thickness of the spherical inserts.
Hot spheres of 10, 20, 30, and 40 mm diameter and a 40-mm hot sphere with a 25-mm solid (cold) centre were inserted into the warm liver background region with a sphere:background ratio of 4 1 and a clinically relevant total activity of 1340 MBq 90Y.
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b Achieved sphere to background activity contrast.
The activity was measured using the PET imaging data and the sphere to background contrast was measured using the pipetted samples.
This study attempts to take the NEMA NU2 image quality test to the next level by reducing the size of the spheres, increasing the number of sphere to background contrast settings, changing the scan times, and changing the reconstructed image voxel size to determine under what scanning conditions can a lesion of a certain size be positively observed.
The mean pixel densities in this sphere were background subtracted, and the median intensity per cell was found using IgorPro.
Sphere and background radioactivity concentration obtained with the dose measurement system was regarded as the gold standard (GS), namely the best estimate of the actual radioactivity concentration.
ROIs were placed in the slice intersecting the spheres center (background, lung insert, biggest and smallest hot spheres).
In Eq. (1),k i is the Bloch wave vector, L i is the lattice constant, n s,i and n b,i are the indices of refraction of the spheres and background materials, respectively, a i and b i are the radius of the spheres and the distance between the spheres, respectively, and ε k is the photon energy.
where Cmeas and Ctrue are the measured and true spheres to background specific activity ratios, respectively.
The ratio of spheres to background activity concentrations was very high (30 1).
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