Exact(3)
Moreover, the speed of relapse depends on both the MM population at the time of transplant as well as the degree of tumour cytoreduction achieved with transplantation.
However, it is also clear that most patients develop resistance to vemurafenib, manifested by progressive disease, and speed of relapse, once resistance is established, can be as rapid as the initial response to the drug.
According to our results, both scenarios are likely to involve populations with large numbers of accumulated driver mutations (or, although not considered in our study, fewer driver mutations but each with larger selective effect), which ostensibly contribute to the speed of relapse.
Similar(57)
Most studies report superior efficacy for combinations versus monotherapy (measured as symptom control, speed of onset, or relapse prevention), but also increased rates of AEs and related discontinuations (Geoffroy et al. [2012]).
No Martin, I've made a full recovery from that affliction, although continuous and tedious abuse from mailer-inners over the (lack of) speed of my updates could cause a relapse at any moment.
Although TBI-containing conditioning seems to be more toxic as compared to its busulfan-containing counterpart, the speed of engraftment, event-free survival and relapse rate are not significantly different (Clift et al, 1994).
The overdoses highlight the high risk of relapse.
Abrupt discontinuation of antidepressants can cause negative side effects and carries the risk of relapse.
Second, the psychological state of craving is the lynch pin of relapse.
Each of us had a history of relapse, and mine was far more extensive.
They are powerful predictors of relapse.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com